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From Wikipedia, the free encyclopedia Antipruritics, abirritants, or anti-itch drugs, are medications that inhibit the itching (Latin: pruritus ) often associated with sunburns, allergic reactions, eczema, psoriasis, chickenpox, fungal infections, insect bites and stings like those from mosquitoes, fleas, and mites, and contact dermatitis and urticaria caused by plants such as poison ivy ( urushiol-induced contact dermatitis ) or stinging nettle,

• It can also be caused by chronic kidney disease and related conditions.
• Abirritants consist of a large group of drugs belonging to different classes with varying mechanisms to treat itch,
• They may work either directly or indirectly to relieve itch, and evidence on their effectiveness varies from one class to another.

Some alternative medicines are also used to treat itch. Side effects of abirritants also vary depending on the class of the drug. Even before the emergence of modern evidence-based medicine, abirritants have already been used in many civilizations, but practices and choice of drugs may differ by culture,

What is an antipruritic drug used for?

Clemastine An antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis. Cyproheptadine A combined serotonin and histamine antagonist used in the treatment of allergic symptoms, for appetite stimulation, and off-label in the treatment of serotonin syndrome.

1. Loratadine A second generation antihistamine used to manage the symptoms of allergic rhinitis.
2. Hydroxyzine An antihistamine used to treat anxiety and tension associated with psychoneuroses, as well as allergic conditions such as pruritus and chronic urticaria.
3. Etotifen A histamine H1 receptor blocker and mast cell stabilizer used to treat mild atopic asthma and allergic conjunctivitis.

Promethazine A first-generation antihistamine used for the treatment of allergic conditions, nausea and vomiting, and motion sickness. Chlorpheniramine A histamine-H1 receptor antagonist indicated for the management of symptoms associated with upper respiratory allergies.

Alimemazine An antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria. Pheniramine An antihistamine used to treat allergic rhinitis and pruritus. Nalmefene An opioid antagonist used to reduce alcohol consumption in adults with alcohol dependence and treat and prevent opioid overdose.

Capsaicin A topical analgesic agent used for the symptomatic relief of neuropathic pain associated with post-herpetic neuralgia, as well as other muscle and joint pain. Dimetindene A 1st generation selective H1 antagonist used topically as an antipruritic and orally to treat allergies.

What is an example of an antipruritic medication?

Common antipruritics Antihistamines such as diphenhydramine (Benadryl) Corticosteroids such as hydrocortisone topical cream. Local anesthetics such as benzocaine topical cream (Lanacaine) Counterirritants, such as mint oil, menthol, or camphor.

What drug is used to stop itching?

Medications that help relieve itching include: Antihistamines (allergy pills): Benadryl (diphenhydramine), Zyrtec (cetirizine), Claritin (loratadine), Clarinex (desloratadine), Allegra (fexofenadine). Anti-itch creams: Topical corticosteroids may be helpful for small itchy areas.

What is the meaning of antipruritic?

Antipruritic.1 of 2 adjective. an·​ti·​pru·​rit·​ic -prü-ˈrit-ik. : tending to check or relieve itching.

How does antipruritics work?

They belong to a class of drugs known as ‘antihistamines.’ Topical antipruritics work in the following ways: They block a natural substance called ‘histamine.’ Histamines are chemicals made by the immune system to help our body get rid of something that’s bothering—an allergy trigger or allergen.

Which antihistamine is Antipruritic?

– PubMed Background and objectives: The causal treatment of chronic pruritus is not always possible or effective necessitating symptomatic antipruritic therapy. Antihistamines are the only drugs approved for the treatment of chronic pruritus, but they are rarely effective at standard doses.

The aim of this investigation was to describe the efficacy and safety of high-dosage antihistamine treatment in patients with chronic pruritus of different origin. Patients: A total of 67 patients with chronic pruritus caused by different skin diseases or chronic pruritus of unknown origin were treated with levocetirizine 10 mg/fexofenadine 360 mg or levocetirizine 10 mg/fexofenadine 360 mg/azelastine 4 mg or desloratadine 20 mg per day.

Results: A therapeutic response was achieved in 43.8% of patients with a combination of two antihistamines, 68.4% of patients with three antihistamines and 76.9% of patients with high dosage desloratadine. The average reduction in pruritus was 57.5% (two antihistamines), 67.4% (three antihistamines) and 89% (desloratadine).

Adverse drug effects were observed rarely. Conclusions: The results of this case series suggest a high antipruritic effect in chronic pruritus by administration of high-dosage, non-sedating antihistamines. These results have to be confirmed in controlled trials. The combination was not more effective than the high dosage monotherapy.

The latter one might be preferable due to unknown interactions and addition of side-effects in the combination therapy. : – PubMed

Which antibiotic is best for itching?

Nystatin and Triamcinolone – Nystatin and Triamcinolone contains antifungal and steroid drugs, prescribed for itching, inflammation, and pain.

What is Pruritic disease?

What is itchy skin (Pruritus)? – Pruritus is the medical term for itchy skin. Normally, itchy skin isn’t serious, but it can make you uncomfortable. Sometimes, itchy skin is caused by a serious medical condition. However, most itchy skin can be treated at home with lotions, moisturizers, and over-the-counter medicines.

Why do antihistamines stop itching?

Eczema is a skin condition that makes skin inflamed, scaly, and itchy. The itch can be intense enough to keep you or your child up at night. And if you scratch too much, you might irritate your skin and start a cycle that makes you itch even more. Antihistamines are medicines that can treat eczema.

Some antihistamines also help you sleep, These medicines won’t stop eczema flares, but they can break the cycle of itching and scratching that makes flares worse. Antihistamines aren’t the main treatment for eczema, but they work together with steroids, moisturizers, and other medicines to control symptoms like itching and sleeplessness.

You may take antihistamines for eczema caused by allergies. Eczema, allergies, and asthma often go together. Doctors call these three conditions the “atopic triad.” If you have eczema you’re likely to have allergies, too. Some antihistamines help you sleep if the eczema itch keeps you awake.

• Your doctor might prescribe what’s called a sedating antihistamine for eczema relief at night.
• Antihistamines aren’t a cure for eczema, but they can help relieve the itchiness it causes.
• The itch can be the most annoying symptom of eczema.
• Sedating antihistamines can help with sleeplessness caused by itching at night.

Histamine is a chemical that your immune system releases when you’re allergic to things like pet hair, pollen, or shellfish. When histamine is released, fluid leaks from your blood vessels into your skin, which leads to swelling, a rash, itching, and other symptoms of an allergic reaction,

1. Antihistamines block histamine to relieve the itch and bring down swelling in your skin.
2. The sedative in some antihistamines relaxes you and makes you sleepy.
3. By helping you sleep, these medications keep you from scratching your skin during the night and irritating it even more.
4. Dyshidrotic eczema is a type of eczema that causes small, fluid-filled blisters on the palms of the hands, sides of the fingers, soles of the feet, and sides of the toes.

The itch from these blisters can be intense. Taking an antihistamine for dyshidrotic eczema may help relieve the itch. Antihistamines come in two main groups: sedating and nonsedating. The best antihistamine for eczema is the one that relieves your symptoms.

Chlorpheniramine (Chlor-Trimeton)Diphenhydramine ( Benadryl, PediaCare Children’s Allergy, ZzzQuil) Doxylamine ( Unisom )

Sedating antihistamines are good at promoting sleep, but they don’t work as well as other eczema medicines at stopping the itch. Second-generation antihistamines are newer medicines. These nondrowsy antihistamines for eczema don’t make you feel as tired, so you can take them during the day. Examples are:

Cetirizine ( Zyrtec ) Fexofenadine ( Allegra ) Loratadine ( Alavert, Claritin )

You can buy both types of antihistamines over the counter without a doctor’s prescription. They come in tablets and capsules. While antihistamines do make babies sleepy, these medicines aren’t recommended for children younger than 4 because young children are more sensitive to the effects of antihistamines.

Heart diseaseHigh blood pressureAbnormal heart rhythmKidney or liver disease Glaucoma Urinary retention

Antihistamines may not be safe for women who are pregnant or breastfeeding. Sedating antihistamines make you sleepy, which could be a problem if you have to drive or operate heavy equipment. Antihistamines for eczema may cause side effects like:

Drowsiness – even the nonsedating ones Dry mouth and eyes Blurry vision Constipation Belly pain Headache

To make sure you take these medicines safely, follow the dosing instructions on the package. If you have any questions about how much to take or to give your child, ask a doctor. Antihistamines are also an ingredient in some over-the-counter cough and cold remedies.

1. Check the ingredients list on any of the medicines you buy.
2. Taking more than one medicine with antihistamines at a time could lead to more side effects.
3. These medicines can also interact with other drugs that make you sleepy.
4. Before you take an antihistamine, let your doctor know if you also take sleeping pills, sedatives, or muscle relaxers.

Histamine is a type of amine, a chemical that forms when bacteria break down proteins. You might notice that your symptoms flare up after you have foods or drinks naturally high in amines, like:

CheeseSmoked meats like salami, ham, and sausagePickled or canned food like sauerkrautShellfish such as shrimp and lobsterChocolateSnacks and sweets that contain preservatives or artificial colorsRed wine

You may want to limit or avoid these foods. A few natural antihistamine foods for eczema are less likely to flare up symptoms:

Fresh meat, fish, chicken, and eggsFresh fruits and vegetablesGrains like oats, rye, and milletFresh pasteurized cow, goat, and sheep milkCream cheese and butter

A food diary can help you pinpoint which foods set off your eczema symptoms and which ones ward off flares. You might also ask a dietitian for help fine-tuning your diet.

Is itching relieved by antihistamines?

People often take antihistamines to relieve itch. Antihistamines, however, do not effectively treat all types of itch. They don’t seem effective for stopping itch due to eczema.

What does antipruritic mean in pharmacology?

Meaning of anti-pruritic in English An antipruritic drug or substance is one that is used to reduce itching (= an uncomfortable feeling on the skin that makes you want to rub it with your nails): Apply an antipruritic cream to reduce itching.