How To Cure Insulin Resistance With Herbs

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How To Cure Insulin Resistance With Herbs
Add herbs and spices to your cooking – Herbs and spices, including fenugreek, turmeric, ginger, cinnamon, and garlic, have shown promising results in increasing insulin sensitivity ( 25, 26 ). Other herbs that may have this effect include basil, dill, fennel, parsley, cumin, nutmeg, oregano, and rosemary.

What is the Chinese medicine for insulin resistance?

Dai-Zong-Fang, A Traditional Chinese Herbal Formula, Ameliorates Insulin Resistance in db/db Mice.

What is the best natural supplement for insulin resistance?

Supplements high in magnesium, berberine, chromium and resveratrol improve insulin sensitivity. Fenugreek, turmeric, ginger, and garlic are a few herbs and spices that have had potential outcomes for improving insulin sensitivity.

What vitamin stops insulin resistance?

How Vitamin D Helps Your Body Use Insulin\ – Another study tied higher vitamin D to a lower risk of insulin resistance, when the body is unable to respond to or use the insulin that it’s producing. Researchers found that the chance of developing insulin resistance went down with each additional amount of vitamin D supplement taken.

How can I get rid of insulin resistance permanently?

Exercise. Physical activity reverses many insulin resistance risk factors and improves insulin sensitivity. Aerobic (cardio) and resistance training (strength) are equally important. Some studies suggest that doing both types of exercise provide greater benefits than doing either one alone.

Can you really reverse insulin resistance?

How can diet affect insulin resistance? – Your diet has a big impact on your blood sugar and insulin levels. Highly processed, high-carbohydrate and high-fat foods require more insulin. In general, eating foods that have a low to medium glycemic index and limiting foods that have a high glycemic index can help you reverse and/or manage insulin resistance.

Eating foods with fiber also helps regulate blood sugar levels because it takes your body longer to digest fiber, meaning your blood sugar levels don’t spike as much. The glycemic index (GI) is a measurement that ranks foods containing carbohydrates according to how much they affect your blood sugar levels.

The Glycemic Index Foundation (GIF) classifies the GI of foods as either low, medium or high, with pure glucose generally as a reference at 100:

Low GI : 55 or less. Medium GI : 56–69. High GI : 70 or greater

High-GI foods generally have a lot of carbohydrates and/or sugar and low to no fiber content. Low-GI foods generally have low amounts of carbohydrates and higher amounts of fiber. Examples of foods with a high GI include:

White bread. Potatoes. Breakfast cereals. Cakes and cookies. Fruits such as watermelon and dates.

Examples of foods with a low GI include:

Beans and legumes. Fruits such as apples and berries. Non-starchy vegetables, such as asparagus, cauliflower and leafy greens. Nuts. Dairy, fish and meat.

Always talk to your healthcare provider before making extreme changes to your diet.

Does coffee spike insulin?

4. Discussion – This meta-analysis evaluated the effects of coffee consumption on HOMA-IR and Matsuda index by analyzing four RCTs. HOMA-IR is used in many studies as a tool for evaluating insulin resistance and mainly reflects liver insulin resistance, This index was more reliable to assess insulin resistance than the fasting glucose/insulin ratio and was an independent predictor of cardiovascular disease, Matsuda index is a simple index of whole-body insulin sensitivity including liver and muscle, Other surrogate indices, except for HOMA-IR and Matsuda, were rarely used in coffee studies. Although not included in the search terms, insulin resistance indices using C-peptide levels (e.g., clamp-like index (CLIX), C-peptide immunoreactivity insulin resistance (CPR-IR)) exist, However, these indices have not been used previously to assess the effects of coffee. A previous meta-analysis reported no significant effect of coffee consumption on HOMA-IR relative to the control by analyzing two RCTs, Our study, which analyzed two more studies, showed that coffee consumption significantly decreased HOMA-IR. However, the robustness of the result was not warranted. The significance of our result was driven by one significant result from a large-weighted study. The weight of the crossover design is generally larger than that of parallel design in a meta-analysis, The characteristics of the group showing significant results were different from those of other studies. They were young adults (aged 18–45 years), had a normal weight (BMI < 25 kg/m 2 ), and did not have any metabolic syndrome including hypercholesterolemia. In such a population, the possibility of coffee consumption lowering insulin resistance cannot be ruled out. However, it is difficult to conclude that coffee consumption reduces insulin resistance from one study. Moreover, coffee consumption did not significantly affect the Matsuda index. Although not included in this meta-analysis, in one non-RCT, HOMA-IR was 3.93, 4.10, and 4.22 in subgroups that consumed zero, four, and eight cups of coffee daily, respectively, The difference was not significant, and other markers of glucose metabolism also were not significantly different, Some studies reported HOMA for β-cell function (HOMA-B) as an indicator of insulin resistance. There was no significant difference in HOMA-B between the coffee consumption and placebo groups in a study by Alperet et al., Mansour et al. conducted an RCT that administered two main coffee components, caffeine and chlorogenic acid, to patients with non-alcoholic fatty liver disease and type 2 diabetes, HOMA-IR between chlorogenic acid plus caffeine, chlorogenic acid, caffeine, and placebo did not differ significantly, Previous studies showed that caffeine can lower insulin sensitivity and increase insulin resistance and glucose concentration, MacKenzie et al. conducted a randomized crossover trial and found that 400 mg of caffeine (equivalent to two cups of coffee) per day decreases insulin sensitivity in young adults, The mechanism of caffeine's effects on glucose metabolism has not been fully revealed, but several have been suggested. Caffeine inhibits glucose uptake and glycogen synthase activity in the skeletal muscle by competitively blocking adenosine receptors, Other mechanisms include increased levels of epinephrine and free fatty acids that can increase insulin resistance after caffeine intake, However, the nonsignificant effects of coffee on insulin resistance and sensitivity in the present meta-analysis might be due to other ingredients in coffee that may negate the effects of caffeine on insulin resistance and sensitivity, Chlorogenic acid reduced glucose concentrations, and its metabolite, quinides, increased insulin sensitivity in rats, Chlorogenic acid may competitively inhibit glucose absorption in the intestine and reduce hepatic glucose output through glucose-6-phosphatase inhibition, This study has several limitations. First, the effects of coffee consumption for more than 24 weeks were not evaluated. This is a limitation of RCTs compared to epidemiologic studies, but a controlled setting (e.g., pre-defined coffee intake, randomly assigned participants) reduces bias and outweighs the disadvantages of an RCT design. Second, the small number of studies limited the evaluation of effect size according to the amount of coffee consumption or caffeine content and the characteristics of the participants through meta-regression. Since coffee is widely consumed and caffeine is addictive, it is difficult to conduct RCTs controlling coffee consumption. Moreover, controlling several confounding variables that affect glucose metabolism (e.g., diet composition and exercise) is difficult. Third, there was heterogeneity in study designs (parallel and crossover). Some researchers recommend combining the results for each research design, which was not done in this meta-analysis due to the small number of included studies.

What Chinese herb lowers blood sugar levels?

Herbal medicine – Herbal medicine has been an integral part of TCM for more than 2,000 years. Many herbal formulations have been developed and are used in the treatment of diabetes. The Huang Di Nei Jing ( Yellow Emperor’s Inner Classic ), which dates from the Han Dynasty 206 B.C.–220 A.D., listed 13 herbal formulations, 9 of which were patent medicines including pills, powders, plasters, and tinctures.12 The sources of Chinese remedies are varied and include plants, minerals, and animal parts.3 Chinese herbs have specific functions (i.e., warming, heat-clearing, eliminating dampness, and cooling) and can be classified according to those functions.

The Chief (principal) ingredient, which treats the principal pattern of disease, The Deputy (associate) ingredient, which assists the Chief ingredient in treating the major syndrome or serves as the main ingredient against a coexisting syndrome, The Assistant (adjutant) ingredient, which enhances the effect of the Chief ingredient, moderates or eliminates the toxicity of the Chief or Deputy ingredients, or can have the opposite function of the Chief ingredient to produce supplementing effects, and The Envoy (guide) ingredient, which focuses the actions of the formula on a certain meridian or area of the body or harmonizes and integrates the actions of the other ingredients.3

Herbal prescriptions for diabetes are formulated or prescribed based on the patient’s predominant symptoms. For instance, a patient presenting primarily with excessive thirst (lung Yin deficiency) might be given a single herb, such as radix panacis quinquefolii; or a combination of herbs in a patent formulation such as yu chuan wan, which is used in general to treat diabetes of mild to moderate severity and specifically to treat excessive thirst due to Yin deficiency,12 and ba wei di huang tang (“eight-ingredient pill with rehmannia”), which was originally used to treat people exhibiting weakness, fatigue, and copious urine soon after drinking water.13 Some of the most commonly used herbal substances for diabetes in TCM include:

Panax ginseng (Korean ginseng), which has a long history of use as a hypoglycemic agent. At least five constituents of this herb have been shown to exert hypoglycemic effects. In one study, treatment with ginseng lowered blood glucose levels and improved mood and psychological performance as compared with placebo. Recommended dosage is 100–200 mg/day.14 Momodica charantia (balsam pear), which is dried, powdered, and made into pills. A dosage of 18 g/day has been shown to reduce blood glucose.15 Lagenaria siceraria (bottle gourd), given as a decoction or pills. The recommended dose is 3 g/day. This, too, has been shown to reduce blood glucose levels.15 Psidium gnajava, taken in the form of fresh leaves or as an infusion and drunk as a tea. The dosage is 9 g/day. It acts to reduce blood glucose levels.15

The above herbs do not appear to increase insulin levels, but rather enhance carbohydrate utilization.15 Patients should have their type of diabetes and any other diagnoses confirmed before initiating any herbal treatment. In addition, one should first ascertain the credibility of the herbal therapist by inquiring about where and for how long the person received training and about membership in herbal associations such as the American Herbalists Guild.

  1. To become members, herbalists must submit three letters of reference from other professional herbalists, a description of their training, and an account of at least 4 years of experience working with medicinal herbs.
  2. As part of their training, TCM practitioners learn about the proper use of herbals.
  3. Many Chinese herbs and formulations have been used safely for centuries in the hands of trained TCM practitioners.

It is important to recognize, however, that data on drug-herb interactions are scarce, and there are clear contraindications to the use of specific herbs in certain populations, such as pregnant women.13 Discontinuing conventional medications in favor of herbal formulations may lead to serious complications such as significant hyperglycemia, and combining conventional hypoglycemic agents with herbal preparations without proper monitoring could lead to hypoglycemia.

The Food and Drug Administration (FDA) does not regulate herbs, minerals, animal products, and patent formulas that come into the United States from China. Herbal products are considered dietary supplements according to the Dietary Supplement and Health Education Act (DSHEA) of 1994; therefore, the manufacturers do not need FDA approval or evaluation for safety, purity, and efficacy before bringing their products to market.

There have been reports of some formulas imported from China containing heavy metals such as lead and mercury and of others being deliberately adulterated with conventional Western pharmaceuticals, such as corticosteroids, anti-inflammatory agents, and benzodiazepines.16

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What Chinese herbs lower blood sugar?

4.1. The Theory of TCM Plays a Fundamental Role in Prescribing TCM in Treatment of T2DM Patients – In this review, for single-herb prescriptions, Ginseng, Bitter melon, Golden Thread, Fenugreek, Garlic, and Cinnamon might have antidiabetic effects in T2DM patients.

Among 30 antidiabetic formulas approved by China SFDA, top 10 of the most frequently prescribed herbs are Membranous Milkvetch Root, Rehmannia Root, Mongolian Snakegourd Root, Ginseng, Chinese Magnoliavine Fruit, Kudzuvine Root, Dwarf Lilyturf Tuber, Common Anemarrhena Rhizome, Barbary Wolfberry Fruit, India Bread, which mainly guided by the theory of TCM.

In spite of diversity of Chinese formulas, some herb components are frequently presented in formulas. Based on the theory of TCM, most of these Chinese herbs investigated can be grouped as Qi (energy)-invigorating, Yin (body fluids)-nourishing, Heat (body heat)-clearing, and Stasis (congested blood circulation or urine)-reducing drugs, and so forth.

  • Diabetes (named Xiaoke in the theory of TCM) is usually associated with the deficiency of both Qi (energy) and Yin (body fluids) and results in the Heat of tissues and blood or urine S tasis (congested blood circulation or urine),
  • This may show the syndromes of Shang Xiao (impairment of the body fluid by the lung-heat), Zhong Xiao (excessive blazing heat in the stomach), and Xia xiao (deficiency of the kidney- Yin, deficiency of both Yin and Yang ) in TCM.

Those prescribed herbs might be effective to treat the diabetic syndromes in TCM. Although the theory of TCM is difficult to understand, it is very useful to direct us to develop effective traditional Chinese herbs with systemic antidiabetic activities.

What is the Chinese herbal formula for diabetes?

RECENT FINDINGS FROM THE SELECTED TRADITIONAL CHINESE MEDICINAL FORMULAS FOR DN TREATMENT – Up to now, there have been many experiments focusing on the treatment of diabetes and its complications with traditional Chinese medicine (TCM) because of less toxicity and/or side effects, if the herbs or Chinese prescriptions are prescribed strictly according to the recommendation of the pharmacopoeia with attention to their origin, dose, way of preparation, and duration of intake.

Following the most general principles of TCM, diabetes affects a patient’s “qi (energy/life-force)” to cause weakness in circulatory system function. In TCM, the spleen is a source of vital energy and blood, and a controller of blood circulation. When spleen qi is weak, its blood controlling function is disturbed; further, the production of blood and “qi” is decreased, leading to ischemia and anoxia of kidney tissue and kidney capillary endothelial cells are damaged.

Once the kidney endothelial cells are damaged, it will attract infiltration of inflammatory cells in the blood circulation and release the pathogenic inflammatory mediators. So, the process of the renal fibrosis is started. Treatment of diabetes by the principles of TCM, therefore, emphasizes improvements of “qi” and circulatory function.

  1. In prescribing formulas, spleen-strengthening formulas such as Wu-Ling-San (WLS; Poria Five Powder; Wǔ Líng Sǎn) could eliminate fluid in the lower and middle body, help dispel moisture, and restore blood circulation.
  2. It should be noted that the scientific basis for the therapeutic effects of TCM, which utilizes herbs for therapy under the guidance of traditional theory, has been established in the literature reports.

Rehmannia Six Formula (RF; Liù Wèi Dì Huáng Wán) is a formula that is commonly used in TCM to treat patients with diabetes. There are six herbs that make up RF, namely Rehmannia glutinosa, Fructus corni, Dioscorea, Poria cocos, Alisma, and Paeonia suffruticosa,

  1. On the basis of the publications found in PubMed during the period 2000–2009, RF appears to have beneficial effects on blood glucose, neuropathy, and nephropathy.
  2. There is also evidence of anti-inflammatory and antioxidant effects.
  3. Pharmacological studies have revealed that other TCM formulas also exert a positive influence on diabetes.

To gather information regarding the use of traditional Chinese formulas in the treatment of DN, we performed a literature search in PubMed using specific search terms such as traditional Chinese formulas and DN. In the current review, we mainly focus on the recent laboratory studies of the TCM formulas including WLS, Danggui-Buxue-Tang (DBT; Dāng Guī Bǔ Xuè Tang), and Danggui-Shaoyao-San (DSS; Dāng Guī Sháo Yào Sǎn), conducted by the Committee on Chinese Medicine and Pharmacy at the Department of Health of Taiwan Government, in the amelioration of DN. The appearance and the weight of each herb in (a) Wu-Ling-San, (b) Danggui-Buxue-Tang, and (c) Danggui-Shaoyao-San

Does apple cider vinegar cure insulin resistance?

How much apple cider vinegar you drink daily can depend on the reason you are taking it. Consuming too much or too often can result in side effects, including wearing down the enamel on your teeth. Apple cider vinegar has been used in cooking and natural medicine for thousands of years.

  1. Many claim it has health benefits, including weight loss, improved blood sugar levels, relief from indigestion, and a decreased risk of heart disease and cancer.
  2. With its many potential uses, it can be difficult to know how much apple cider vinegar to take each day.
  3. Dosage recommendations can vary, but taking 1–2 tablespoons (tbsp.), or 15–30 milliliters (mL), of apple cider vinegar with water before or after meals may be beneficial.

This article outlines how much apple cider vinegar you should drink for different health benefits, as well as the best ways to avoid side effects. Apple cider vinegar is often recommended as a natural way to control blood sugar levels, especially for people with insulin resistance,

When taken before a high carb meal, vinegar slows the rate of stomach emptying and prevents large blood sugar spikes ( 1 ). It also improves insulin sensitivity, which helps your body move more glucose out of the bloodstream and into your cells, thus lowering blood sugar levels ( 2 ). Interestingly, only a small amount of apple cider vinegar is needed to have these effects.

Generally, taking 4 teaspoons (tsp.), or 20 mL, of apple cider vinegar before meals has been shown to significantly reduce blood sugar levels after eating ( 2, 3 ). It should be mixed with a few ounces (oz.) of water and consumed right before a high carb meal ( 1 ).

Apple cider vinegar does not significantly lower blood sugar when taken before a low carb or high fiber meal ( 4 ). Summary Drinking 4 tsp. (20 mL) of apple cider vinegar diluted in water immediately before a high carb meal can reduce blood sugar spikes. Polycystic ovarian syndrome (PCOS) is a hormonal condition associated with abnormal menstrual cycles, high levels of androgen hormones, ovarian cysts, and insulin resistance ( 5 ).

One older 3-month study found that females with PCOS who drank 1 tbsp. (15 mL) of apple cider vinegar with about 7 oz. (100 mL) of water immediately after dinner had improved hormone levels and experienced more regular periods ( 6 ). While further research is needed to confirm these results, 1 tbsp.

  1. 15 mL) each day appears to be an effective dose for improving PCOS symptoms.
  2. Summary Regularly drinking 1 tbsp.
  3. 15 mL) of apple cider vinegar with about 7 oz.
  4. 100 mL) of water after dinner may improve symptoms of PCOS.
  5. Though more research is needed on the long-term effects of vinegar, it may help people lose weight by suppressing appetite when consumed alongside a meal ( 7 ).

In one 2009 study, 1 or 2 tbsp. (15 or 30 mL) of apple cider vinegar daily for 3 months helped people with overweight lose an average of 2.6 and 3.7 pounds (lbs.), or 1.2 and 1.7 kilograms (kg), respectively ( 8 ). Taking 2 tbsp. each day have also been found to help people lose nearly twice as much weight in 3 months compared to people who didn’t consume apple cider vinegar ( 9 ).

  • However, a recent review concluded that there is insufficient evidence to support the use of apple cider vinegar for weight loss.
  • Therefore, more high quality research is needed ( 10 ).
  • You can stir it into a glass of water and drink it before meals or mix it with oil to make a salad dressing.
  • Apple cider vinegar is more likely to aid weight loss when combined with other diet and lifestyle changes,

Summary Drinking 1–2 tbsp. (15–30 mL) of apple cider vinegar each day for several months may increase weight loss in people with overweight. However, more research is needed. Many people take apple cider vinegar before high protein meals to improve digestion.

  • The theory is that apple cider vinegar increases the acidity of your stomach, which helps your body create more pepsin, the enzyme that breaks down protein ( 11 ).
  • While there is no research to support the use of vinegar for digestion, other acidic supplements, such as betaine HCL, may help significantly increase the acidity of the stomach ( 12 ).

Acidic foods like apple cider vinegar may have similar effects, but more research is needed. Those who take apple cider vinegar for digestion typically drink 1 to 2 tbsp. (15–30 mL) with a glass of water immediately before meals, but there is currently no evidence to support this dose.

Summary Some claim drinking 1 to 2 tbsp. (15–30 mL) of apple cider vinegar before meals can aid digestion. However, there is currently no research to support this practice. Other popular reasons for taking apple cider vinegar include protecting against heart disease, reducing the risk of cancer, and fighting infection.

There is limited scientific evidence to support these claims, and no recommended dosages for humans are available. Animal and test-tube studies suggest that vinegar may reduce the risk of heart disease, protect against cancer, and slow the growth of bacteria, but no studies have been performed in humans ( 13, 14, 15 ).

Several studies have found that people who regularly eat salads with vinegar-based dressings tend to have a lower risk of heart disease and less belly fat, but this could be due to other factors ( 9, 16 ). More human research is needed to understand the best dose of apple cider vinegar for general health and wellness.

Summary There is no evidence that apple cider vinegar can protect against heart disease, cancer, or infection in humans, so no dosage recommendations can be made. Apple cider vinegar is relatively safe to consume but can cause side effects in some people.

Since apple cider vinegar’s acidity is responsible for many of its health benefits, be sure not to mix it with anything that could neutralize the acid and reduce its positive effects ( 17 ). Keep in mind that vinegar’s acidity may also damage tooth enamel with regular use. Drinking through a straw and rinsing your mouth with water afterward can help prevent this ( 18, 19 ).

While drinking apple cider vinegar is associated with health benefits, regularly consuming large amounts for long periods can be dangerous and may be linked to side effects, including low blood potassium levels ( 20 ). If you experience uncomfortable side effects after taking apple cider vinegar, stop taking it and discuss these symptoms with a doctor.

Summary Apple cider vinegar is relatively safe in small quantities but may erode tooth enamel or cause stomach upset in some people. Large amounts may be unsafe to consume over long periods of time. Apple cider vinegar can help manage blood sugar, improve symptoms of PCOS, and promote weight loss. A typical dose is 1–2 tbsp.

(15–30 mL) mixed with water and taken before or after meals. Research doesn’t support claims that it can improve digestion and prevent heart disease, cancer, or infection. Apple cider vinegar is a relatively safe supplement to consume in moderation but has not been extensively researched.

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Does magnesium help insulin resistance?

Introduction – Magnesium is an abundant mineral in the human body that functions as a structural component of enzymes and a catalytic co-factor, which plays an important role as a calcium antagonist ( 1 ). It is required for the synthesis of DNA, RNA, and the antioxidant glutathione and contributes to the structural development of bones ( 2 ).

Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse biochemical reactions in the body, including protein synthesis, blood glucose control, blood pressure regulation, and muscle and nerve functions ( 3 ). Magnesium is also required for energy production, oxidative phosphorylation, and glycolysis ( 4 ).

Diabetes mellitus (DM) comprises a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both ( 5 ). Type 2 diabetes mellitus, previously referred to as noninsulin-dependent diabetes, or adult-onset diabetes, encompasses individuals who have insulin resistance (IR) and usually have relative insulin deficiency ( 6 ).

  • IR is a pathological situation characterized by impairment of insulin-mediated glucose transport to peripheral cells, which is due to the lack of physiological response of peripheral tissues to insulin action and leads to the metabolic and hemodynamic disturbances known as metabolic syndrome ( 7 ).
  • Increasing attention has been given to the role of certain elements in the pathogenesis of diabetes mellitus, and recent studies have demonstrated the participation of minerals in glucose metabolism disorders in humans ( 8 ).

Magnesium participates directly in this process by acting as a cofactor for many enzymes involved in energy metabolism and modulating insulin secretion and action in target tissues through interaction with receptors of this hormone ( 9, 10 ). Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency, having 25% to 39% prevalence ( 5 ).

There are many causes for low magnesium levels in diabetes, which include low magnesium diet, osmotic diuresis, which leads to high renal excretion of magnesium, insensitivity to insulin, which affects intracellular magnesium transport and causes increased loss of extracellular magnesium, usage of loop and thiazide diuretics, which promote magnesium wasting, diabetic autonomic neuropathies, and reduced tubular reabsorption due to IR ( 11 ).

Many experimental models for diabetes were developed, which include surgical procedures, chemical induction, and the use of spontaneous or genetically derived animal strains. Chemical methods of inducing damage to the pancreatic β-cells are obtained through the administration of drugs such as streptozotocin (STZ), a nitrosourea derivative isolated from Streptomyces achromogenes ( 12 ).

β-cell toxicity and diabetogenic properties of STZ are mediated through diverse mechanisms including targeted uptake of STZ in β-cells by Glut2 receptors and increased oxidative stress due to nitric oxide release and reactive oxygen species production ( 13 ). At the appropriate doses, these drugs act by selectively destroying the pancreatic β-cells ( 12, 14 ).

Insulin receptor is a large transmembrane protein, which consists of two alpha chains and two beta chains connected by disulfide bonds ( 15 ). During the action state of insulin, it first binds to the insulin receptor causing structural change in the insulin receptor alpha chain to release the inhibition towards the beta chain.

Then the beta chain autophosphorylates the tyrosine kinase domains for downstream signaling activation ( 16 ). Changes in the intracellular magnesium concentration can regulate the insulin receptor at the gene transcriptional and translational levels by modulating DNA and ribosome structures ( 17 ). Alternative splicing occurs during transcription of the insulin receptor gene, which produces two types of mRNAs that translate into high affinity or low-affinity insulin receptors.

There are fewer high-affinity insulin receptors but they bind to insulin with high specificity and efficiency. Meanwhile, there are more low-affinity insulin receptors, which have larger capacity to bind to insulin with lower affinity but long-lasting effect.

  1. Insulin receptor affinity represents the insulin receptor binding capacity, which is indicated by the binding constant ( 15, 18 ).
  2. Studies have shown that tissue insulin receptor affinity is significantly down-regulated in insulin-resistant diabetic patients ( 19 ).
  3. Currently, it has been shown that elderly type 2 diabetes patients have relatively low serum magnesium levels, which correlates with reduced insulin sensitivity ( 19 ).

In this study, we used the high-fat diet and STZ-induced rat model of type 2 diabetes to examine the effect of magnesium supplementation on insulin sensitivity.

Is fasting good for insulin resistance?

The primary physical benefit of intermittent fasting is improvement of metabolic health by lowering insulin resistance. While its effect on insulin levels can promote weight loss – what many people strive for – it can have many other powerful benefits for the body.

How much vitamin D to reverse insulin resistance?

Patients with insulin resistance who are vitamin D deficient should be treated with an appropriate amount of vitamin D to achieve circulating levels of 25(OH)D of 40–60 ng/mL. –

Does vitamin D reduce insulin resistance?

Discussion – The main purpose of this study was to investigate the effects of vitamin D supplementation on glucose homeostasis. The results showed that vitamin D supplementation significantly decreased serum FPG,insulin and HOMA-IR in patients with T2DM.

  1. The role of basal serum FPG and vitamin D, sex, and HbA1c in predicting FPG final was 36%.
  2. There was an interesting finding.
  3. There was an inverse relation between final FPG and basal 25(OH) D concentration.
  4. In other words, higher serum basal 25(OH) D led to lower final FPG.
  5. This means that who had a higher serum basal 25(OH) D concentration benefited more of vitamin D intake to lowering final FPG.

This may be because of non-skeletal effects of vitamin D which appears in higher vitamin D concentration and the effects of lower vitamin D concentration, are limited to the bone and muscle. Our data showed that effects of vitamin D on insulin resistance was significant when vitamin D concentration was 40–60 ng/ml(100–150 nmol/l) and in lower and upper vitamin D concentration, it didn,t affect on insulin resistance.

Effects of vitamin D supplementation on glucose homeostasis have been shown in numerous studies. Our findings are consistent with results of many other published studies, in which the insulin resistance appears to be decreased in T2DM patients who had received vitamin D. For example,Inzucchi showed a 60% improvement in insulin sensitivity by increased serum 25 (OH)D concentration from 10 to 30 ng/ml(25 to75nmol/l), by which metformin or troglitazone were 54% and 13% respectively,

Von Hurst (2009) showed that vitamin D supplementation significantly improved insulin sensitivity and insulin resistance, Ken (2004) found an inverse relation between 25(OH) vitamin D concentration and FPG, but a direct relation with insulin sensitivity,

As to these studies, our study shows that mean FPG was significantly reduced after increased vitamin D intake. Monthly supplementation with 120,000 units of vitamin D also improved insulin sensitivity, Although in contrast to some studies, there was a significant reduction in HOMA-IR after taking vitamin D, Witham foundout that vitamin D intake (at different dosage) had no effects on insulin resistance or on HbA1c as did Lind,

Nagpal reported that vitamin D supplementation had no effect on mean of insulin sensitivity but two years treatment with vitamin D did improve HOMA-IR, There are some mechanisms for the effects of vitamin D: presence of vitamin D receptors on pancreatic β cells, Vitamin D activating 1α hydroxylase is expressed in pancreatic β cells, presence of vitamin D response element in the insulin gene, presence of vitamin D receptor in skeletal muscle and the fact that 1,25(OH)D increases transcription of insulin receptor genes, and also suppresses the renin gene reducing hyperglycemic-induced increases in renin levels in pancreatic β cells and blockade of renin-angiotensin activity has been proposed as a novel target for diabetes treatment,

Protective effects of vitamin D on diabetes,maybe due to well known effects of vitamin D such as its anti-inflammatory properties, its effects on calcium and phosphorus metabolism and regulation of the insulin receptor gene, It seems that vitamin D increases in calcium content of the cells, in turns leading to increased transport of glucose into the muscle,

Vitamin D also regulates nuclear PPAR (Peroxisome proliferative activated receptor)that has an important role in the insulin sensitivity, vitamin D deficiency is associated with increases in inflammation. Vitamin D attenuates the expression of proinflammatory cytokines involved in insulin resistance such as interleukins, IL-1, IL-6, TNF-a, also down regulates NF-Kb (Nuclear factor) activity,

It would be useful, though to undertake further studies to discover more about the mechanism and the effect of vitamin D on both alpha and islet beta-cell function and also on the mechanisms determining insulin resistance. Some Iranian studies also showed that calcitriol,vitamin D injection and vitamin D intake could,nt affect on diabetes and insulin resistance,

Although some of them reported significant effects of vitamin D on diabetes, A limitation of our study is that we did not evaluate the effects of placebo on FPG, insulin or HOMA-IR. However, there are a few studies that didn’t use placebo, evaluated the effects of vitamin D at different doses on glucose homeostasis,

What minerals reverse insulin resistance?

Chromium Since the discovery of chromium (Cr) as an essential trace metal in 1955, it has been found to effectively improve glucose tolerance by reducing insulin resistance.

What are the warning signs of insulin resistance?

Learn about insulin resistance from Eleanna De Filippis, M.D., Ph.D., an endocrinologist at Mayo Clinic. Hello. I’m Dr. Eleanna De Filippis, an endocrinologist at Mayo Clinic. In this video, we’ll cover the basics of insulin resistance. What is it? Who gets it? The symptoms, diagnosis and treatment.

Whether you’re looking for answers for yourself or someone you love, we’re here to give you the best information available. To understand insulin resistance, often referred to as prediabetes, let’s first talk about what insulin does. When you eat food, your body converts that food into dietary sugars.

Insulin is a hormone released by the pancreas that tells your cells to open up to that sugar and convert it into energy. With insulin resistance, the cells don’t react, and don’t open up, resulting in excessive sugar in the blood. Over time, the pancreas keeps trying to regulate the blood sugar, producing more and more insulin until it wears out and can’t produce large amounts of insulin anymore.

  1. As a result, blood sugar levels increase to the point of being in the diabetic range.
  2. Who gets it? Anyone can become insulin-resistant.
  3. In particular, people with excess weight are at a higher risk, compared to the general population.
  4. Risk is further increased with a family history of type two diabetes, age over 45, African, Latino or Native American ancestry, smoking, and certain medications, including steroids, anti-psychotics, and HIV medication.

There are other medical conditions associated with insulin resistance, like obstructive sleep apnea, fatty liver disease, polycystic ovarian syndrome, also known as PCOS, Cushing’s syndrome, and lipodystrophy syndromes. Lipodystrophy syndromes are conditions that cause abnormal fat loss.

So carrying either too much or not enough fat tissue in your body can be associated with insulin resistance. What are the symptoms? Very often people with insulin resistance don’t have any symptoms at all. It is usually picked up by their doctor during an annual health exam or routine blood work. There are some signs of insulin resistance that your doctor may look for.

These includes a waistline over 40 inches in men, and a waistline over 35 inches in women. Skin tags or patches of dark velvety skin called acanthosis nigricans. A blood pressure reading of 130 over 80 or higher. A fasting glucose level equal or above 100 milligrams per deciliter.

Or a blood sugar level equal or above 140 milligrams per deciliter two hours after a glucose load test. An A1C between 5.7% and 6.3%. A fasting triglycerides level over 150 milligram per deciliter. And an HDL cholesterol level under 40 milligrams per deciliter in men, and an HDL cholesterol level under 50 milligrams per deciliter in women.

How is it diagnosed? If your doctor spots these symptoms, they may follow up with a physical exam and a variety of blood tests that measure the levels of glucose, or sugar, in your blood and/or your tolerance to that glucose. Or more recently, a blood test called hemoglobin glycosylated A1C, often simply referred to as A1C.

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How is it treated? Reversing insulin resistance and preventing type two diabetes is possible through lifestyle changes, medication, or sometimes both. Healthy bodies come in different shapes and sizes. Losing weight through drastic means can be dangerous and counterproductive. Instead, get ideas from a doctor or a nutritionist about ways to incorporate healthy foods like fruits, vegetables, nuts, beans, and lean proteins into your meals.

Also, consider incorporating exercise and movement into your day-to-day life in ways that make you feel good. What now? Even though permanently defeating insulin resistance isn’t always possible, you can help your body to be more receptive to insulin.

Why am I becoming insulin resistant?

What Causes Insulin Resistance? – It isn’t clear exactly what causes insulin resistance, but a family history of type 2 diabetes, being overweight (especially around the waist), and being inactive all can raise the risk. You do not have to be overweight to have insulin resistance. You can’t tell if someone has insulin resistance by looking at them.

How long will it take to reverse insulin resistance?

Book Title :The Diabetes Code Book Author : Jason Fung Publication Information : Vancouver, Canada, Greystone Books, 2018, 296 pp., $22.95 Jason Fung, MD uses Ockham’s razor to si mplify the management of type 2 diabetes. William of Ockham (1287-1347) was an English friar and philosopher.

He is famous for postulating that with complex problems, the hypothesis with the fewest assumptions is usually correct.1 Fung is a nephrologist by training and runs the Intensive Dietary Management Program at the University of Toronto. Fung formulated a new understanding of obesity by developing the argument that obesity is a hormonal illness of excess insulin.2 With all food consumption, especially carbohydrates, insulin is secreted to drive blood sugar into cells.

Insulin is more importantly a fat storage hormone that blocks the burning of fat and causes excess sugar to be turned into fat through lipogenesis. Repeatedly eating carbohydrates causes chronically high insulin levels and the steady accumulation of fat.

Fung stresses the importance of fasting to lower insulin levels enough to begin using body fat for energy. He argues that nutrition for weight loss has been overly focused on what is eaten, and not sufficiently focused on how often we eat. Humans have spent most of their time on earth eating just one meal a day.

Eating three meals a day is cultural, and contributes to the epidemic of overweight and obesity, especially with the increased intake of refined carbohydrates.3 In The Diabetes Code, Fung furthers this same argument to show that type 2 diabetes is caused by insulin resistance.

  1. Doctors have known this for a long time, but Fung simplifies it for a better understanding of how insulin resistance occurs.
  2. The repeated secretion of insulin that causes obesity next leads to insulin resistance as a protective mechanism for chronically high insulin levels.
  3. This also results in fatty liver early in the disease process.

Insulin resistance results in the high blood sugar of type 2 diabetes. Overcome insulin resistance, and the blood sugar returns to normal and the type 2 diabetes is reversed. Fasting is a key part of this disease reversal process. The approach to preventing and reversing diabetes described in The Diabetes Code is straightforward.

  • The nutrition is healthy fats, low carbohydrates, and intermittent fasting.
  • Healthy nutrition continues for life with good fats: nuts, seeds, fatty fruits and vegetables such as avocado, quality fish, and meat.
  • This is a version of the Mediterranean diet.
  • All refined carbohydrates and sugars are avoided.

Twelve to 16-hour fasting periods are built into the daily routine, and adults eat one to two meals a day. Water is encouraged to stay well hydrated, and coffee and tea are allowed during fasting periods. Any snacks should be healthy fat and low carbohydrate, such as raw nuts.

Bone broth or similar foods are used during prolonged fasts to maintain electrolytes. Obese patients with long-standing insulin resistance often require a prolonged fast to get them started for burning fat, losing weight, and reversing insulin resistance. Fung shows how fat burning does not occur until the insulin levels are low, such as a fasting insulin below 10 mIU/ml.

Fung uses longer fasting periods to lower insulin levels, allowing the body to recover from insulin resistance. To avoid hunger from fluctuating blood sugar levels, the patient is first weaned off refined carbohydrates and started on the healthy fat low carbohydrate diet.

A minimum initial prolonged fast of 36 hours to 3 days may be needed to start the process of reversing insulin resistance. For morbidly obese patients Fung uses initial fasts of 7 to 21 days. The longest known medically supervised fast is over 1 year in a male weighing more than 460 lbs. Micronutrients, ample water, and electrolytes are provided during the fast, and coffee and tea are allowed.

Fung describes how many of the drugs used to treat type 2 diabetes, while lowering the blood sugar, make the underlying disease worse by increasing body fat and increasing insulin resistance. The biggest culprit here is the use of insulin. In the United States, over 23 billion dollars were spent on drugs for type 2 diabetes in 2013.4 In Fung’s clinic at the University of Toronto, most of the patients with type 2 diabetes have a complete reversal of the disease and are off medications in 3 to 6 months.

  • With The Diabetes Code, Fung provides a simple lifestyle approach to preventing and avoiding what has become the most expensive of all chronic diseases.
  • The food industry and the drug industry will not be excited by his method, but it is long overdue for the public to curb the epidemic of obesity and diabetes, and lower the costs of medical care.

The methods described by Fung should be taught to medical students and residents, and used in family medicine offices as part of a lifestyle approach to promoting health.

How long does it take for insulin resistance to reverse?

Book Title :The Diabetes Code Book Author : Jason Fung Publication Information : Vancouver, Canada, Greystone Books, 2018, 296 pp., $22.95 Jason Fung, MD uses Ockham’s razor to si mplify the management of type 2 diabetes. William of Ockham (1287-1347) was an English friar and philosopher.

He is famous for postulating that with complex problems, the hypothesis with the fewest assumptions is usually correct.1 Fung is a nephrologist by training and runs the Intensive Dietary Management Program at the University of Toronto. Fung formulated a new understanding of obesity by developing the argument that obesity is a hormonal illness of excess insulin.2 With all food consumption, especially carbohydrates, insulin is secreted to drive blood sugar into cells.

Insulin is more importantly a fat storage hormone that blocks the burning of fat and causes excess sugar to be turned into fat through lipogenesis. Repeatedly eating carbohydrates causes chronically high insulin levels and the steady accumulation of fat.

  1. Fung stresses the importance of fasting to lower insulin levels enough to begin using body fat for energy.
  2. He argues that nutrition for weight loss has been overly focused on what is eaten, and not sufficiently focused on how often we eat.
  3. Humans have spent most of their time on earth eating just one meal a day.

Eating three meals a day is cultural, and contributes to the epidemic of overweight and obesity, especially with the increased intake of refined carbohydrates.3 In The Diabetes Code, Fung furthers this same argument to show that type 2 diabetes is caused by insulin resistance.

Doctors have known this for a long time, but Fung simplifies it for a better understanding of how insulin resistance occurs. The repeated secretion of insulin that causes obesity next leads to insulin resistance as a protective mechanism for chronically high insulin levels. This also results in fatty liver early in the disease process.

Insulin resistance results in the high blood sugar of type 2 diabetes. Overcome insulin resistance, and the blood sugar returns to normal and the type 2 diabetes is reversed. Fasting is a key part of this disease reversal process. The approach to preventing and reversing diabetes described in The Diabetes Code is straightforward.

  1. The nutrition is healthy fats, low carbohydrates, and intermittent fasting.
  2. Healthy nutrition continues for life with good fats: nuts, seeds, fatty fruits and vegetables such as avocado, quality fish, and meat.
  3. This is a version of the Mediterranean diet.
  4. All refined carbohydrates and sugars are avoided.

Twelve to 16-hour fasting periods are built into the daily routine, and adults eat one to two meals a day. Water is encouraged to stay well hydrated, and coffee and tea are allowed during fasting periods. Any snacks should be healthy fat and low carbohydrate, such as raw nuts.

  1. Bone broth or similar foods are used during prolonged fasts to maintain electrolytes.
  2. Obese patients with long-standing insulin resistance often require a prolonged fast to get them started for burning fat, losing weight, and reversing insulin resistance.
  3. Fung shows how fat burning does not occur until the insulin levels are low, such as a fasting insulin below 10 mIU/ml.

Fung uses longer fasting periods to lower insulin levels, allowing the body to recover from insulin resistance. To avoid hunger from fluctuating blood sugar levels, the patient is first weaned off refined carbohydrates and started on the healthy fat low carbohydrate diet.

A minimum initial prolonged fast of 36 hours to 3 days may be needed to start the process of reversing insulin resistance. For morbidly obese patients Fung uses initial fasts of 7 to 21 days. The longest known medically supervised fast is over 1 year in a male weighing more than 460 lbs. Micronutrients, ample water, and electrolytes are provided during the fast, and coffee and tea are allowed.

Fung describes how many of the drugs used to treat type 2 diabetes, while lowering the blood sugar, make the underlying disease worse by increasing body fat and increasing insulin resistance. The biggest culprit here is the use of insulin. In the United States, over 23 billion dollars were spent on drugs for type 2 diabetes in 2013.4 In Fung’s clinic at the University of Toronto, most of the patients with type 2 diabetes have a complete reversal of the disease and are off medications in 3 to 6 months.

  • With The Diabetes Code, Fung provides a simple lifestyle approach to preventing and avoiding what has become the most expensive of all chronic diseases.
  • The food industry and the drug industry will not be excited by his method, but it is long overdue for the public to curb the epidemic of obesity and diabetes, and lower the costs of medical care.

The methods described by Fung should be taught to medical students and residents, and used in family medicine offices as part of a lifestyle approach to promoting health.

Can insulin resistance reverse itself?

How can I prevent or reverse insulin resistance and prediabetes? – Physical activity and losing weight if you need to may help your body respond better to insulin. Taking small steps, such as eating healthier foods and moving more to lose weight, can help reverse insulin resistance and prevent or delay type 2 diabetes in people with prediabetes. Physical activity can help prevent or reverse insulin resistance and prediabetes. The National Institutes of Health-funded research study, the Diabetes Prevention Program (DPP), showed that for people at high risk of developing diabetes, losing 5 to 7 percent of their starting weight helped reduce their chance of developing the disease.3 That’s 10 to 14 pounds for someone who weighs 200 pounds.

  1. People in the study lost weight by changing their diet and being more physically active.
  2. The DPP also showed that taking metformin, a medicine used to treat diabetes, could delay diabetes.
  3. Metformin worked best for women with a history of gestational diabetes, younger adults, and people with obesity.

Ask your doctor if metformin might be right for you. Making a plan, tracking your progress, and getting support from your health care professional, family, and friends can help you make lifestyle changes that may prevent or reverse insulin resistance and prediabetes.