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Roxithromycin vs Cefixime: –

Roxithromycin	Cefixime
Roxithromycin is a macrolide antibiotic that treats bacterial infections of the throat, airways, tonsils, lungs, skin, and urinary tract, which includes kidneys, bladder, ureters, and urethra.	Cefixime is used to treat infections that are caused by bacteria. There are various bacterial infections like bronchitis, gonorrhoea and infections of ears, throat, tonsils and urinary tract.
The medication is mainly used for the treatment of bacterial infections. It is used to cure the infections like tonsils, sinus, ear, nose, throat, skin and soft tissues.	Cefixime is used for curing bacterial infections which include: Infection in the middle ear Tonsillitis Throat infections
Some of the common and major side effects of Roxithromycin are: Nausea Vomiting Abdominal pain Diarrhea	Some of the common cefixime side effects are: Diarrhea Stomach Pain Gas Heartburn

Does roxithromycin help cough?

Roxithromycin attenuates acid-induced cough and water-induced bronchoconstriction in children with asthma – PubMed In the present study, we evaluated the effect of roxithromycin, a semisynthetic macrolide antibiotic, on the cough response to inhaled acetic acid (AA) and on the bronchoconstriction induced by ultrasonically nebulized distilled water (UNDW) in children with asthma.

• Ten hospitalized asthmatic children (8 boys and 2 girls, mean +/- SEM age 12.6 +/- 0.4 years) were enrolled in this study.
• They were treated with 150 mg of roxithromycin once a day orally for 8 weeks without any side effects.
• All the patients underwent AA inhalation challenge before and 2, 4, and 8 weeks after the administration of roxithromycin.

Seven of the 10 patients, who had a fall in FEV1 of at least 20% after UNDW inhalation, underwent UNDW inhalation challege at the same time. The cough threshold values, the lowest concentrations of AA eliciting coughs, and UNDW provocative dose producing a 20% fall in FEV1 (UNDW PD20) values 4 or 8 weeks after the administration of roxithromycin increased significantly over the initial values (p : Roxithromycin attenuates acid-induced cough and water-induced bronchoconstriction in children with asthma – PubMed

Is roxithromycin stronger than amoxicillin?

J Fam Pract,2002 April;51(4):329-336 A Double-Blind Randomized Controlled Trial ABSTRACT OBJECTIVE: To assess the efficacy of roxithromycin relative to amoxicillin. STUDY DESIGN: We conducted a double-blind randomized controlled trial of oral 500 mg amoxicillin 3 times per day vs oral 300 mg roxithromycin once a day for 10 days.

1. POPULATION: We included 196 adults who had presented to a general practitioner with lower respiratory tract infection (LRTI) and, in the physician’s opinion, needed antibiotic treatment.
2. OUTCOMES MEASURED: We measured clinical response after 10 and 28 days, defined in 4 ways: (1) decrease in LRTI symptoms; (2) complete absence of symptoms; (3) decrease in signs; and (4) complete absence of signs.

Self-reported response included the decrease in symptoms and the time until resumption of impaired or abandoned daily activities on days 1 through 10, 21, and 27. RESULTS: Clinical cure rates after the completion of antibiotic treatment (10 days) were not significantly different for the 2 groups.

After 28 days, the roxithromycin group showed no increase in cure rate as evidenced by the decrease in symptoms, indicating a significantly lower cure rate. However, this difference did not alter physicians’ overall conclusion after complete follow-up that 90% of patients, regardless of age, had been effectively treated with either amoxicillin or roxithromycin.

CONCLUSIONS: The surplus value of roxithromycin was not confirmed. Amoxicillin remains a reliable first-choice antibiotic in the treatment of LRTI in general practice. KEY POINTS FOR CLINICIANS

Amoxicillin and roxithromycin are equally effective in the treatment of patients presenting with lower respiratory tract infections and needing antibiotic treatment.Most patients remain symptomatic after 10 days of treatment with either drug.The low incidence of atypical pathogens ( Mycoplasma pneumoniae, Legionella pneumophila, and Chlamydia pneumoniae ) in the Netherlands minimizes the potentially greater surplus value of macrolide antibiotics over amoxicillin.

Acute community-acquired lower respiratory tract infections (LRTIs) in adults include acute bronchitis, pneumonia, and infectious episodes in patients with asthma or chronic obstructive pulmonary disease (COPD). In acute bronchitis and exacerbations of COPD, the value of antibiotic therapy is doubtful; in pneumonia, however, it is widely accepted.

Because distinguishing between these disease entities on clinical grounds alone is often impossible, deciding which patients would benefit from antibiotic treatment remains difficult.1 – 6 In the Netherlands, as in the United States and Great Britain, antibiotics are prescribed for patients with acute bronchitis approximately 80% of the time.7 – 9 If a primary care physician (PCP) decides to treat LRTI with antibiotics, amoxicillin is the drug of first choice in the Netherlands.10 – 13 However, amoxicillin is not effective in infections caused by atypical organisms such as Mycoplasma pneumoniae, Chlamydia pneumoniae, and Legionella pneumophila, which are responsible for 1% to 50% of cases of LRTI.14 – 20 Roxithromycin and the newer macrolide antibiotics are recommended as drugs of choice for the empirical treatment of community-acquired pneumonia in low-risk patients in the United States and Canada 21 – 23 because those drugs cover both typical and atypical pathogens.

Amoxicillin has long proved to be a reliable drug and one to which the resistance of common respiratory tract pathogens ( Streptococcus pneumoniae and Haemophilus influenzae ) in the Netherlands is low.24 – 29 Community-based studies that evaluate treatment for LRTI are lacking.

• Also lacking are independent randomized controlled studies comparing amoxicillin with roxithromycin or other new macrolides for LRTI.
• Our double-blind randomized trial attempted to determine whether the preference for amoxicillin in the Netherlands is well founded.
• In the trial, patients with LRTI who in their PCP’s opinion needed antibiotic treatment were assigned to either amoxicillin or roxithromycin.

We then compared the efficacy and safety of both drugs. Methods Eligibility criteria and baseline characteristics Eligible study subjects were patients in the southern part of the Netherlands who presented with signs and symptoms of LRTI that their PCPs believed warranted antibiotic therapy.

1. Table 1 lists the inclusion and exclusion criteria.
2. Baseline data (at day 1) were obtained to evaluate the comparability of prognostic factors between the intervention groups.
3. The PCP performed an extensive medical history and physical examination.
4. In addition, a sputum sample, oral washing, and nasopharyngeal swab were taken for bacteriologic examination.

Venous blood samples were taken for blood chemistry, hematology, and serology (initial titers of the viral pathogens M pneumoniae and L pneumophila ). TABLE 1 CHECKLIST FOR PATIENT ELIGIBILITY

Inclusion Criteria	Exclusion Criteria
A : Age 18 years or older	Pregnant or present wish to become pregnantBreastfeedingTerminal diseaseDrug or alcohol abuseHistory of hypersensitivity to penicillins or macrolidesHospital stay in previous 4 weeks for respiratory complaintsTreatment with antibiotics within preceding 14 daysTreatment with any other investigational drug within 4 weeks before entry into the trialHistory of severely impaired hepatic or renal functionMental condition rendering the patient unable to understand the nature, scope, and possible consequences of the study or evidence of uncooperative attitudeInability to attend follow-up visitsImmunocompromised statusRequired admission to hospitalConcomitant treatment with ergot alkaloids or terfenadine during the study period
AND
B : New* or increasing cough
AND
C : At least 1 of the following:
1) Shortness of breath
2) Wheezing
3) Chest pain
4) Auscultation abnormalities
AND
D : At least 1 of the following:
1) Fever (≥ 38°C)
2) Perspiring
3) Headache
4) Myalgia
AND
E : Diagnosis of LRTI according to PCP and
F : Antibiotics required (in PCP’s opinion)
* Onset within the previous 29 days.
LRTI denotes lower respiratory tract infection; PCP, primary care physician.

How long should I take roxithromycin?

One roxithromycin 150 mg tablet morning and evening. The usual duration of treatment is five to ten days depending on the indication and clinical response. Streptococcal throat infections require ten days of therapy. The duration of treatment should not exceed ten days.

Who should not take roxithromycin?

Roxithromycin is not recommended for children less than 40 kg in weight. Swallow roxithromycin tablets whole with a glass of water. Roxithromycin should be taken at least 15 minutes before food or on an empty stomach (that is, more than 3 hours after a meal). Roxithromycin works best if you take it on an empty stomach.

What is the best antibiotic for long cough?

Amoxicillin-clavulanate acid is the most commonly used antibiotic, as first-line, prolonged therapy (longer than 2 weeks) is sometimes required to cough resolution.

What is the best antibiotic for cough?

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1. If you continue to have this issue please contact [email protected],
2. Antibiotics are an appropriate and effective option for the treatment of wet or productive cough in children, with literature supporting the use of amoxicillin clavulanate or erythromycin, according to a Cochrane review.

“Our knowledge of childhood wet cough has progressed greatly in the last decade. We now know that one of the most common causes of childhood chronic wet cough is protracted bacterial bronchitis in Australia, Europe and similar populations,” Julie M. Marchant, PhD, a senior research fellow at the Child Health Research Center in South Brisbane, Australia, told Infectious Diseases in Children,

” has now been incorporated into pediatric cough guidelines worldwide.” Marchant said that although the findings of this review were not a surprise to her, the broader medical community may still be unaware of studies on the topic. To examine how effective antibiotic treatment is in children with chronic wet cough without bronchiectasis or other previously known respiratory illness — as well as the risk of adverse events related to treatment — the researchers conducted a review of three randomized controlled trials.

Each trial included a placebo group for comparison, and cluster or cross-over trials were excluded from the review. Marchant and colleagues said two of the studies had high or unclear risk of bias and one had a low risk of bias. The duration of treatment ranged from 7 to 14 days.

Two studies used amoxicillin clavulanate acid for the treatment of wet cough, whereas one used erythromycin. Of the 190 children aged between 21 months and 6 years included in the meta-analysis, 171 completed treatment. When antibiotics were used for treatment, children were more likely to be cured at follow-up (OR = 0.15; 95% CI, 0.07-0.31).

The researchers noted that two of the trials examined the progression of illness related to wet cough, which was defined as the need for additional antibiotics. This was required for 125 children. Children who received antibiotics were significantly less likely to need additional treatment (OR = 0.1; 95% CI, 0.03-0.34).

• All three trials reported adverse events, but a significant increase in risk was not observed between the antibiotic groups compared with the control groups (OR = 1.88; 95% CI, 0.62-5.69).
• Current guidelines suggest the use of amoxicillin clavulanate as first-line therapy except in cases of allergy,” Marchant said.

“This is because the most common organisms found on bronchoalveolar lavage in children with chronic wet cough are Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis, and amoxicillin-clavulanic acid is an antibiotic with broad coverage of these organisms.

In contrast, with the increasing emergence of macrolide resistance to these common pathogens may limit their usefulness in the future, and macrolide antibiotics like erythromycin are not recommended as first-line treatment.” – by Katherine Bortz Disclosures: The authors report no relevant financial disclosures.

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What are the top 3 antibiotics?

Top 10 most prescribed antibiotics of 2022

Rank	DRUG name	Explore dataset
1	Amoxicillin	Explore
2	Azithromycin	Explore
3	Amoxicillin and Clavulanate Potassium	Explore
4	Cephalexin	Explore

Is roxithromycin a good antibiotic?

Roxithromycin vs Cefixime: –

Roxithromycin	Cefixime
Roxithromycin is a macrolide antibiotic that treats bacterial infections of the throat, airways, tonsils, lungs, skin, and urinary tract, which includes kidneys, bladder, ureters, and urethra.	Cefixime is used to treat infections that are caused by bacteria. There are various bacterial infections like bronchitis, gonorrhoea and infections of ears, throat, tonsils and urinary tract.
The medication is mainly used for the treatment of bacterial infections. It is used to cure the infections like tonsils, sinus, ear, nose, throat, skin and soft tissues.	Cefixime is used for curing bacterial infections which include: Infection in the middle ear Tonsillitis Throat infections
Some of the common and major side effects of Roxithromycin are: Nausea Vomiting Abdominal pain Diarrhea	Some of the common cefixime side effects are: Diarrhea Stomach Pain Gas Heartburn

Can I take paracetamol with roxithromycin?

Can we take Roxithromycin with paracetamol? Yes, it is safe to take paracetamol with Roxithromycin. Paracetamol is a safe painkiller in most cases and hardly causes adverse effects. Hence, it can be used with a wide range of antibiotics.

What are the side effects of roxithromycin?

SIDE EFFECTS – Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Roxithromycin Sandoz. All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.

• oral thrush with a white, furry, sore tongue and mouth
• vaginal thrush with a sore and itchy vagina and/or discharge
• nausea, vomiting, stomach pain, diarrhoea, flatulence, loss of appetite
• red and/or itchy skin, skin rash
• headache, tiredness, dizziness, pins and needles, ringing in the ears
• hallucinations
• altered taste and/or smell.
• Blurred vision and /or visual impairment

These are mild side effects of the medicine, and are short-lived. Tell your doctor as soon as possible if you notice any of the following, in particular if they occur several weeks after you finished taking Roxithromycin Sandoz:

• severe abdominal or stomach cramps
• watery and severe diarrhoea, which may even be bloody
• fever, in combination with one or both of the above.

The above list includes serious side effects of Roxithromycin Sandoz. These side effects are rare. You may suffer from a serious condition affecting your bowel requiring medical attention. Check with your doctor before taking any diarrhoea medication. If any of the following happen stop taking this medicine and tell your doctor immediately or go to Accident and Emergency at your nearest hospital:

• severe persistent diarrhoea
• frequent infections such as fever, severe chills, sore throat or mouth ulcers
• swelling of the face, lips, mouth and tongue
• difficulty in swallowing or breathing
• an allergic reaction (for example, itchy skin, rash, swelling, asthma or wheezing)
• severe skin rash.
• Sever blisters and bleeding in the lips, eyes, mouth, nose and genitals

The above list includes very serious side effects. If you have them, you may have had a serious allergic reaction to Roxithromycin Sandoz. You may need urgent medical attention or hospitalisation. These side effects are very rare. Tell your doctor or pharmacist if you notice anything else that is making you feel unwell. Other side effects not listed above may also occur in some people.

What happens if I take roxithromycin with food?

ARROW – ROXITHROMYCIN works best if you take it on an empty stomach. Food in the stomach can reduce the absorption of ARROW – ROXITHROMYCIN. Take the tablet at about the same time of each day. Taking your tablet at the same time each day will have the best effect on your infection.

What are the side effects of the drug Roximycin?

Frequent infections such as fever, severe chills, sore throat or mouth ulcers severe persistent diarrhoea swelling of the face, lips, mouth and tongue difficulty in swallowing and breathing an allergic reaction (for example, itchy skin, rash, swelling, asthma) severe skin rash These are very serious side

Can you drink alcohol while taking roxithromycin?

Q: Can I consume alcohol with roxithromycin? A: Avoid consuming alcohol with roxithromycin, as it may worsen the side effects.

Can you drink alcohol while taking roxithromycin 150mg?

Roxithromycin doesn’t have a direct interaction with alcohol. This means that most people could have the occasional drink while taking it without any serious problems. However, if roxithromycin makes you feel sick (nausea), don’t drink alcohol as it will make you feel worse.

How do you know if cough is bacterial or viral?

In addition to lab tests, sputum or mucus from a cough can be visually examined to determine whether bronchitis is viral, bacterial, or both. Clear or white mucus often indicates a viral infection, while yellow or green mucus may suggest a bacterial infection.

Is it normal to still be coughing up phlegm after antibiotics?

Your cough may persist for two to three weeks after you finish your course of antibiotics, and you may feel tired for even longer as your body continues to recover. Drink plenty of fluids to avoid dehydration, and get plenty of rest to help your body recover.

Do antibiotics cure coughs?

There are other ways to treat your child’s symptoms. – Antibiotics kill bacteria but they do not treat symptoms of an illness, such as ear pain, fever, cough or congestion.

Fever is treated with an ‘anti-pyretic’ such as ibuprofen or acetaminophen, It is important to know the correct dose to give your child. Pain, such as ear pain or throat pain, is treated with ibuprofen or acetaminophen, As always, it is important to know the correct dose to give your child. Congestion can be helped by using a humidifier, Cough can be helped by a spoonful of dark honey if your child is over 1 year of age.

Ask your doctor about treatments to help your child’s symptoms.

Do I need antibiotics for a bad cough?

Important – Antibiotics are not normally prescribed for coughs. A GP will only prescribe them if you need them – for example, if you have a bacterial infection or you’re at risk of complications.

Will my cough get better without antibiotics?

Treatment from a GP for a chest infection – Treatment for a chest infection will depend on the cause. A chest infection will either be caused by:

• a virus (like viral bronchitis ) – this usually clears up by itself after a few weeks and antibiotics will not help
• bacteria (like pneumonia) – a GP may prescribe antibiotics (make sure you complete the whole course as advised by the GP, even if you start to feel better)

Antibiotics are only used to treat bacterial chest infections. They’re not used for treating viral chest infections, like flu or viral bronchitis. This is because antibiotics do not work for viral infections. You may need a blood test or a sample of your mucus may need to be tested to see what’s causing your chest infection.

What medicine is good for coughing with mucus?

What are the different types of expectorants? – Expectorants can be classified as medicinal or natural. The main ingredient in medicinal expectorants helps thin the secretions in your airway. By thinning those secretions, it makes your cough more productive. Medicinal expectorants are available over-the-counter in liquid, pill and tablet forms. Medicinal expectorants include:

Guaifenesin : Guaifenesin is the most commonly used expectorant. It is the active ingredient in medicines including Mucinex® and Robitussin®. You can find guaifenesin in many common cough, cold and flu medications. In addition, guaifenesin is an active ingredient in over-the-counter decongestants, cough suppressants, antihistamines and pain and fever medications. Guaifenesin is currently the only expectorant approved by the U.S. Food and Drug Administration. Guaifenesin hydrates your mucus in order to reduce its stickiness. Potassium iodide : Potassium iodide is a prescription-strength expectorant. Your healthcare provider may prescribe potassium iodide if you have a chronic lung disease. Chronic lung diseases can produce excessive mucus, which can complicate your disease. These diseases include asthma, bronchitis and pulmonary emphysema. Potassium iodide helps loosen mucus and makes it easier to cough.

Natural expectorants are another option if you’re trying to loosen up mucus and relieve chest congestion. Natural expectorants include:

Menthol : Menthol is a natural chemical that comes from plants in the mint family. Menthol is a common ingredient in cough drops (throat lozenges) and cough syrups. Menthol gives you a cooling sensation and can sometimes soothe a sore throat, One study determined that menthol may relax your airway muscles. This allows more air to enter your respiratory system to help improve your cough. Ivy leaf extract : Ivy leaf extract is a natural expectorant known for its effects on mucus production. One study said that any medications containing dry ivy extract may be effective at treating coughs. Oral hydration : No matter what kind of expectorant you use, keeping hydrated is important. Drink extra water or make a cup of tea to increase your fluid intake. Avoid alcohol and caffeine as much as you can. Steam : Inhaling warm, moist air can do wonders for a persistent cough. The steam can help loosen the mucus in your airway. Take a long shower or use a humidifier to get extra moisture into your lungs. Honey : Honey may help loosen up mucus and relieve your cough. You can add honey to a cup of tea or even mix it with warm milk. But don’t give honey to babies younger than 12 months old — they have an increased risk of botulism,

Do antibiotics stop coughing?

Antibiotics don’t help a night cough or a cough with mucus. And they don’t improve your quality of life. Taking antibiotics too often or when you don’t need them can be harmful.

Can antibiotics cure cough?

There are other ways to treat your child’s symptoms. – Antibiotics kill bacteria but they do not treat symptoms of an illness, such as ear pain, fever, cough or congestion.

Fever is treated with an ‘anti-pyretic’ such as ibuprofen or acetaminophen, It is important to know the correct dose to give your child. Pain, such as ear pain or throat pain, is treated with ibuprofen or acetaminophen, As always, it is important to know the correct dose to give your child. Congestion can be helped by using a humidifier, Cough can be helped by a spoonful of dark honey if your child is over 1 year of age.

Ask your doctor about treatments to help your child’s symptoms.

Is roxithromycin good for a cold?

ROXITHROMYCIN: Uses, Side Effects and Medicines ROXITHROMYCIN belongs to the group of antibiotic medicines called macrolides. ROXITHROMYCIN is a broad-spectrum antibiotic that is used to treat respiratory tract, gastrointestinal, skin and soft tissue infections.

• Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body.
• Infectious or harmful bacteria can make you sick and reproduce quickly in your body.
• These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick.
• ROXITHROMYCIN works by interfering with the protein synthesis of the bacteria, which is necessary for their survival.

Thereby, helps in treating and preventing the spread of infections. ROXITHROMYCIN does not work against infections caused by the virus, including cold and flu. Take ROXITHROMYCIN as prescribed. In some cases, you may experience certain common side-effects such as nausea, headache, dizziness, stomach upset, diarrhoea, rash and stomach ache.

1. Most of these side-effects do not require medical attention and will resolve gradually over time.
2. However, you are advised to talk to your doctor if you experience these side-effects persistently.
3. Do not take antacids medicines along with ROXITHROMYCIN; maintain a gap of 2 hours between both.
4. Avoid taking ROXITHROMYCIN if you are pregnant or breastfeeding unless prescribed by a doctor.

ROXITHROMYCIN may reduce the effectiveness of contraceptives, consult your doctor before taking ROXITHROMYCIN if you are using contraceptives. ROXITHROMYCIN may cause dizziness, so be cautious while driving. Avoid alcohol consumption to prevent unpleasant side-effects.

Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side-effects. ROXITHROMYCIN is a broad-spectrum antibiotic that is effective against gram-positive and gram-negative bacteria. ROXITHROMYCIN works by interfering with the protein synthesis of the bacteria, which is necessary for their survival.

Thereby, helps in treating and preventing the spread of infections. Take ROXITHROMYCIN on empty stomach or 15minutes before food. Tablet/capsule: Swallow it as a whole with water; the tablet should not be crushed or chewed. Oral liquid: Shake the bottle well before use.

Nausea Headache Dizziness Stomach upset Diarrhoea Rash

Do not take ROXITHROMYCIN if you are allergic to any of its contents, if you are taking ergot alkaloids (used to treat migraine), terfenadine or astemizole (used to treat allergy), cisapride (used to treat acidity), or pimozide (used to treat psychosis).

1. Do not take ROXITHROMYCIN on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections.
2. Talk to your doctor before taking ROXITHROMYCIN if you have heart, kidney or liver problems, hypokalaemia (low potassium levels), diarrhoea, or if you weigh below 60kgs.

Do not take antacids medicines along with ROXITHROMYCIN; maintain a gap of 2hours between both. ROXITHROMYCIN may reduce the effectiveness of contraceptives, consult your doctor before taking ROXITHROMYCIN if you are using contraceptives. Avoid taking ROXITHROMYCIN if you are pregnant or breastfeeding unless prescribed by a doctor.

Drug-Drug Interactions: ROXITHROMYCIN may have interaction with terfenadine, astemizole (used to treat allergy), cisapride (used to treat acidity), pimozide, thioridazine (used to treat psychosis), disopyramide (used to treat heart conditions), ergotamine, dihydroergotamine (used to treat migraine), midazolam (used to treat sleepiness), ciclosporin (used in organ transplantation), theophylline (used to treat asthma), dofetilide (used to treat irregular heartbeat) and warfarin (used to prevent blood clotting). Drug-Food Interactions: No interactions found/established. Drug-Disease Interactions: ROXITHROMYCIN may have interactions with heart, kidney and liver disease.

CISAPRIDEPIMOZIDEDISOPYRAMIDETHEOPHYLLINEDOFETILIDEWARFARINTERFENADINEASTEMIZOLEERGOTAMINEDIHYDROERGOTAMINEMIDAZOLAM

Is roxithromycin good for chest infection?

Roxithromycin Uses – The medication is mainly used for the treatment of bacterial infections. It is used to cure the infections like tonsils, sinus, ear, nose, throat, skin and soft tissues. It works by preventing the synthesis of essential proteins that bacteria need to perform their functions.